This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Evaluation by High-Frequency Audiometry

Teresa I. McRorie, PharmD; John Bosso, PharmD; Loren Randolph, MS

Am J Dis Child. 1989;143(11):1328-1332.

Abstract
• In this study, we sought to determine the clinical usefulness of high-frequency audiometry (8000 to 20 000 Hz) in detecting aminoglycoside-induced increases in pure-tone hearing thresholds before they are noticed in conventionally tested frequencies. We measured hearing thresholds from 250 to 20 000 Hz in 22 patients with cystic fibrosis who were treated with aminoglycosides. The audiograms were age-matched and were compared with those from 13 patients with cystic fibrosis and 38 subjects without cystic fibrosis, all of whom had never received aminoglycoside therapy. In patients with cystic fibrosis who were treated with aminoglycoside (younger than 20 years), there were statistically significant elevations only in frequencies higher than 16000 Hz. Patients with cystic fibrosis who were treated with aminoglycosides who were 20 years and older had elevated thresholds in all frequencies tested. Patients with cystic fibrosis who were not treated with aminoglycosides did not differ statistically from controls. High-frequency audiometry may serve as a useful measure of elevation in pure-tone hearing thresholds that precede noticeable loss of auditory acuity in patients with cystic fibrosis who are receiving long-term aminoglycoside therapy.

(AJDC. 1989;143:1328-1332)

Author Affiliations
From the Department of Pharmacy Practice, School of Pharmacy (Drs McRorie and Bosso), and the Division of Otolaryngology, School of Medicine (Ms Randolph), University of Utah, Salt Lake City. Dr McRorie is now with the Department of Pharmacy Practice, School of Pharmacy, University of Washington, Seattle.

Footnotes
Accepted for publication May 1, 1989.

Presented in part at the Ninth Annual Meeting of the American College of Clinical Pharmacy, Philadelphia, Pa, July 28, 1988.

Reprint requests to Department of Pharmacy Practice, SC-69, University of Washington, Seattle, WA 98195 (Dr McRorie).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Aminoglycoside Prescribing and Surveillance in Cystic Fibrosis
Tan et al.
Am. J. Respir. Crit. Care Med. 2003;167:819-823.
FULL TEXT