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Growth Hormone Treatment in Children With Sporadic Primary Microcephaly
Gian Luigi Spadoni, MD;
Stefano Cianfarani, MD;
Sergio Bernardini, MD;
Vaccaro Fabrizio, MD;
Cinzia Galasso, MD;
Brunetto Boscherini, MD
Am J Dis Child. 1989;143(11):1282-1283.
Abstract
Four children with sporadic primary microcephaly associated with short stature, delayed bone age, and low growth velocity are described. All of the children showed a normal growth hormone response to standard pharmacological tests but one of the patients had a reduced spontaneous growth hormone nocturnal secretion. Regardless of the results of their somatotropic function evaluation, the patients were treated with exogenous growth hormone and all of them showed an increase in growth rate.
(AJDC. 1989;143:1282-1283)
Author Affiliations
From the Department of Pediatrics, Second University of Rome, Italy.
Footnotes
Accepted for publication December 22, 1988.
Reprint requests to Clinica Pediatrica, Dipartimento di Sanità Pubblica, 2a Università di Roma, Via Orazio Raimondo, 00173 Roma, Italy (Dr Spadoni).
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