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Reye's SyndromeA Reappraisal of Diagnosis in 49 Presumptive Cases
Marie Gauthier, MD;
Joanne Guay, MD;
Jacques Lacroix, MD;
Anne Lortie, MD
Am J Dis Child. 1989;143(10):1181-1185.
Abstract
• We retrospectively studied 49 patients who were discharged from Sainte-Justine Hospital, Montreal, Canada, or who died between 1970 and 1987 with a presumptive diagnosis of Reye's syndrome. Reye's syndrome was defined as certain, probable, unlikely, or excluded according to clinical, biological, and histologic criteria agreed on a priori by a panel of experts. Patient charts were reviewed blindly by three clinicians. Assessments were similar in 42 cases (86%) (weighted  = 0.78 to 0.85, which suggested substantial agreement); for the remainder, agreement was reached after discussion. Reye's syndrome was considered certain in 1 case (2%), probable in 11 (22%), unlikely in 21 (43%), and excluded in 15 (31%). Four children in the study group did not undergo biopsy or autopsy; in three of these, Reye's syndrome was unlikely according to clinical and biological criteria, and in one, the diagnosis was unclassifiable. The incidence of certain or probable Reye's syndrome was low in our institution during the study period. Our results suggest that the apparent disappearance of Reye's syndrome should be reassessed.
(AJDC. 1989;143:1181-1185)
Author Affiliations
From the Departments of Pediatrics and Anesthesia, Sainte-Justine Hospital, University of Montreal, Canada.
Footnotes
Accepted for publication March 20, 1989.
Presented in part at the 17th Annual Society of Critical Care Medicine Symposium, Orlando, Fla, June 1, 1988.
Reprint requests to Department of Pediatrics, Hôpital Sainte-Justine, 3175 Côte Ste-Catherine, Montréal, H3T 1C5 Québec, Canada (Dr Gauthier).
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