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Age-Specific Characteristics of Brain Death in Children
James C. Fackler, MD;
Juan C. Troncoso, MD;
Frank R. Gioia, MD
Am J Dis Child. 1988;142(9):999-1003.
Abstract
Clinical and neuropathologic characteristics of 45 children who met criteria for brain death were analyzed. Children between 2 months and 1 year of age were compared with children older than 1 year and children older than 5 years. The observation period to fulfill brain death criteria was not different between the age groups. Deep tendon and spinal reflexes were preserved significantly less frequently in children younger than 1 year old. Diabetes insipidus and the necessity of inotropic support were significantly more frequent in children older than 5 years. Fifty-eight percent (26/45) of patients had no cerebral perfusion pressure before death. However, 18% (8/45) of patients never had a cerebral perfusion pressure below 40 mm Hg. No relationships could be shown between the clinical or physiologic factors and neuropathologic findings. We found no support for using different brain-death criteria for children between 2 months and 1 year of age.
(AJDC 1988;142:999-1003)
Author Affiliations
From the Departments of Anesthesiology/Critical Care Medicine (Drs Fackler and Gioia) and Pathology (Dr Troncoso), The Johns Hopkins Hospital, Baltimore. Dr Fackler is now with The Children's Hospital, Boston.
Footnotes
Accepted for publication Feb 25, 1988.
Reprint requests to Department of Anesthesiology, The Children's Hospital, 300 Longwood Ave, Boston, MA 02115 (Dr Fackler).
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