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In Vitro Effects of Magnesium on Ionized Calcium Concentration in Serum
Chao-Li Liu, MD;
Francis Mimouni, MD;
Mona Ho,, MS;
Reginald Tsang, MBBS
Am J Dis Child. 1988;142(8):837-838.
Abstract
• Hypermagnesemic neonates, born to mothers receiving magnesium (Mg) sulfate before delivery, have elevated ionized calcium (iCa) concentrations in serum. We hypothesized that this elevation might be due in part to competition of Mg with calcium (Ca) bound to proteins or complexed to salts. Serum and its ultrafiltrate were obtained from five placental blood samples. The iCa concentration was measured in both serum and its ultrafiltrate at five incremental Mg concentrations ( Mg) up to 6.58 mmol/L. In both serum and ultrafiltrate, incremental iCa ( iCa) correlated significantly with Mg. By multiple regression analysis, ica in serum correlated positively with Mg in serum and negatively with albumin concentration in serum. Thus, iCa concentration in serum is increased in vitro by hypermagnesemia; it appears that Mg may compete with Ca bound to albumin and complexed to salts.
(AJDC 1988;142:837-838)
Author Affiliations
From the Division of Endocrinology and Metabolism, Beijing Children's Hospital, People's Republic of China (Dr Liu), and the Division of Neonatology, Department of Pediatrics, University of Cincinnati, College of Medicine (Drs Mimouni and Tsang and Ms Ho).
Footnotes
Accepted for publication March 7, 1988.
Reprint requests to Division of Neonatology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267-0541 (Dr Mimouni).
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