Naproxen nephrotoxicity in a 2-year-old child
P. E. Ray, D. Rigolizzo, D. R. Wara and C. F. Piel
Department of Pediatrics, University of California, San Francisco.
The development of acute renal failure and interstitial nephritis due to
therapeutic doses of nonsteroidal anti-inflammatory drugs has been
documented repeatedly in adult patients but is rare in children. We report
the occurrence of this complication in a child. Acute renal failure and
hyperkalemia developed in a 2-year-old boy with juvenile rheumatoid
arthritis after one month of naproxen sodium therapy. The evidence of renal
toxic effects became manifest after an episode of dehydration. A
percutaneous renal biopsy specimen revealed interstitial nephritis. The
patient recovered promptly after withdrawal of the drug.
