Factors associated with infantile hypertrophic pyloric stenosis
M. B. Jedd, L. J. Melton 3rd, M. R. Griffin, B. Kaufman, A. D. Hoffman, D. Broughton and P. C. O'Brien
Mayo Medical School, Mayo Clinic, Rochester, MN 55905.
We examined perinatal factors in relation to the rise in incidence of
infantile hypertrophic pyloric stenosis among children in Olmsted County,
Minnesota, during the period from 1950 through 1984. Primogeniture was
associated with male infants but not female infants; some factor related to
primogeniture, such as breast-feeding, may be etiologically important. Our
data did not support a role for maternal disease, use of doxylamine
succinate-pyridoxide hydrochloride (Bendectin), or an infectious process.
Further study should be directed toward environmental factors associated
with primogeniture.
