This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Selective Role of Thromboxane Mediation

Cathy Hammerman, MD; Karl Komar, MD; Hussein Abu-Khudair, MD

Am J Dis Child. 1988;142(3):319-325.

Abstract
• Pulmonary hypertension was generated in 11 newborn piglets, via either infusion of group B β-hemolytic streptococci (n=5) or induction of isocapnic hypoxia (n=6), to study the contributions of thromboxane metabolite thromboxane B₂ levels to different types of pulmonary hypertension. After 30 minutes of stable pulmonary hypertension, mean (± SD) pulmonary artery pressure increased similarly from 16±4 to 33±5 mm Hg (hypoxic), and from 14±2 to 34±6 mm Hg (septic). All other measured hemodynamic variables were similar. Despite these hemodynamic similarities, there were significant differences in thromboxane B₂ levels. After 60 minutes of pulmonary hypertension, thromboxane B₂ levels were 760±253 pg/mL (hypoxic), and 3103±1083 pg/mL (septic). These data demonstrate that, while thromboxane appears to be crucial in mediating septic pulmonary hypertension in the piglet, it is not associated with hypoxic pulmonary hypertension, implying that different types of pulmonary hypertension are probably mediated by different biochemical agents.

(AJDC 1988;142:319-325)

Author Affiliations
From the Department of Pediatrics, Division of Newborn Medicine, University of Chicago.

Footnotes
Accepted for publication Nov 12, 1987.

Presented at the National Society of Pediatric Research Meetings, Anaheim, Calif, April 28, 1987.

Reprint requests to Department of Pediatrics, Box 325, University of Chicago, 5825 Maryland Ave, Chicago, IL 60637 (Dr Hammerman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Thromboxane hypersensitivity in hypoxic pulmonary artery myocytes: altered TP receptor localization and kinetics
Hinton et al.
Am. J. Physiol. Lung Cell. Mol. Physiol. 2007;292:L654-L663.
ABSTRACT | FULL TEXT  

Hypoxia induces hypersensitivity and hyperreactivity to thromboxane receptor agonist in neonatal pulmonary arterial myocytes
Hinton et al.
Am. J. Physiol. Lung Cell. Mol. Physiol. 2006;290:L375-L384.
ABSTRACT | FULL TEXT