Dense metaphyseal bands and growth arrest associated with isotretinoin therapy
J. C. Marini, S. Hill and M. A. Zasloff
Human Genetics Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892.
A 9-year-old boy, treated with high-dose isotretinoin therapy for
fibrodysplasia ossificans progressiva, developed dense metaphyseal bands
and growth arrest. Discontinuance of isotretinoin therapy was followed by
gradual decrease of metaphyseal bands and resumption of clinical growth.
The dense metaphyseal bands may be related to the known action of retinoids
as modulators of chondrocyte phenotype and gene expression.
