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Cryptosporidium, Malnutrition, and Chronic Diarrhea in Children
Sarah Sallon, MD;
Richard J. Deckelbaum, MD, CM;
Irmgard I. Schmid;
Susan Harlap, MB;
Mario Baras, PhD, MD;
Dan T. Spira, PhD
Am J Dis Child. 1988;142(3):312-315.
Abstract
• Cryptosporidium was found in the stools of 13.5% of 221 children hospitalized with diarrhea. It was the single most prevalent pathogen isolated. Children with Cryptosporidium-positive stools were significantly more malnourished than children in whom Cryptosporidium was not detected. Children with more severe malnutrition (ie, less than 50% of their expected weight) and with Cryptosporidium in their stools had a significantly longer duration of diarrhea than similarly malnourished children without Cryptosporidium (63 vs 32 days, respectively). In 77 better-nourished outpatients with diarrhea, Cryptosporidium was found in only 5.2% of cases and was associated with lesssevere illness. Our findings are consistent with the hypothesis that in less-developed areas, Cryptosporidium is a major pathogen, not only in acute but also in chronic childhood diarrhea, and may play an important role in the interaction between diarrhea and malnutrition.
(AJDC 1988;142:312-315)
Author Affiliations
From the Kuvin Center for the Study of Infectious and Tropical Diseases, The Hebrew University Hadassah Medical School, Jerusalem, Israel.; Dr Sallon is a Reitman Fellow of the Children's Nutritional Disease Project, Canadian Friends of Hebrew University. Dr Deckelbaum is now with the College of Physicians & Surgeons of Columbia University, NY.
Footnotes
Accepted for publication July 1, 1987.
Reprint requests to the Department of Pediatrics, College of Physicians & Surgeons of Columbia University, 630 W 168th St, New York, NY 10032 (Dr Deckelbaum).
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