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Takahiro Nara, MD; Hidetsugu Nozaki, MD; Youichiro Nakae, MD; Takashi Arai, RT; Toya Ohashi, MD

Am J Dis Child. 1988;142(2):173-174.

Abstract
• Sequential examination of neuronspecific enolase in cerebrospinal fluid and serum was performed in 20 comatose children with acute encephalitis, acute encephalopathy, or Reye's syndrome. Neuron-specific enolase activities corresponded to the degree of brain damage. As neuron-specific enolase levels increased to greater than 80 ng/mL, patients had more severe impairment or died. Neuron-specific enolase may be a useful marker for evaluating the degree of neuronal damage and prognosis.

(AJDC 1988;142:173-174)

Author Affiliations
From the Division of Neurology (Drs Nara, Nozaki, and Nakae) and the Department of Radiology (Mr Arai), Saitama (Japan) Children's Medical Center; and the Department of Pediatrics (Dr Ohashi), Jikei University School of Medicine, Tokyo.

Footnotes
Accepted for publication Sept 1, 1987.

Reprint requests to Division of Neurology, Saitama Children's Medical Center, 2100 Magome, Iwatsuki, Saitama 339, Japan (Dr Nara).

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