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  Vol. 142 No. 10, October 1988 TABLE OF CONTENTS
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Necrotizing tracheobronchitis. An ischemic lesion

J. B. Hanson, G. Waldstein, J. A. Hernandez and L. L. Fan
Department of Perinatology, Children's Hospital, Denver, CO 80218.

Neonates with necrotizing tracheobronchitis present a diverse clinical spectrum from asymptomatic disease to severe airway obstruction. A retrospective clinicopathologic study of 206 neonatal autopsy reports spanning a three-year period yielded 122 cases of necrotizing tracheobronchitis with an incidence of 59%. All study patients received treatment prior to the development of high-frequency ventilator jet, oscillator, or interruption. The site and submucosal depth of airway involvement was variable. The most commonly affected anatomic site was the middle or thoracic trachea (56%). The common cause identified was severe ischemia to the airway mucosa and submucosa, occurring with profound birth asphyxia and/or shock. The presence of ischemia supports the concept that decreased tracheoperfusion may be an important factor in the development of tracheobronchial abnormalities.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Pneumomediastinum in dermatomyositis: association with cutaneous vasculopathy
Kono et al.
Ann Rheum Dis 2000;59:372-376.
ABSTRACT | FULL TEXT  





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