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Plasma Prorenin and Renin in Childhood and Adolescence
Darrell M. Wilson, MD;
David K. Stevenson, MD;
John A. Luetscher, MD
Am J Dis Child. 1988;142(10):1070-1072.
Abstract
• We studied 108 subjects (age range, 4 to 76 years) to determine the effect of age on prorenin (inactive renin), active renin, and plasma renin activity in normal children, adolescents, and adults. Children and adolescents had lower prorenin concentrations and higher plasma renin activity and active renin concentrations than did adults. Prorenin concentrations were positively correlated with age over the range of 4 to 76 years, while plasma renin activity and active renin concentration were negatively correlated with age. Plasma prorenin and active renin concentrations from umbilical cord blood samples obtained from 11 newborns and arterial samples obtained from five infants were higher than those in samples obtained from children or adults.
(AJDC 1988;142:1070-1072)
Author Affiliations
From the Departments of Pediatrics (Drs Wilson and Stevenson) and Medicine (Dr Luetscher), Stanford (Calif) University.
Footnotes
Accepted for publication May 26, 1988.
Presented in part at the Western Society for Pediatric Research, Carmel, Calif, Feb 18, 1988.
Reprint requests to S-322, Medical Center, Stanford University, Stanford, CA 94305 (Dr Wilson).
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