A comparison of combinations of diuretics in nephrotic edema
E. H. Garin
The metolazone-furosemide combination of diuretics was compared with the
thiazide-furosemide combination in nephrotic patients with edema. Nine
patients underwent a crossover, randomized study receiving furosemide (2
mg/kg per dose) and either metolazone (dose varied according to weight) or
chlorothiazide (10 mg/kg per dose). An additive natriuretic and diuretic
effect was observed after both metolazone and thiazide were combined with
furosemide. The use of both types of diuretic combination was associated
with marked kaliuresis. These combinations of diuretics seem equally
effective in inducing natriuresis and diuresis in edematous nephrotic
patients.
