Hepatocarcinoma in a child with the Alagille syndrome
S. S. Kaufman, R. P. Wood, B. W. Shaw Jr, R. S. Markin, B. Gridelli and J. A. Vanderhoof
A child with the Alagille syndrome of intrahepatic bile duct paucity
developed hepatocarcinoma. Disabling cirrhosis had rendered this child a
suitable candidate for transplantation before the discovery of carcinoma.
However, the extension of the tumor outside the liver precluded the
performance of this potentially life-saving operation. Serial monitoring of
the serum alpha-fetoprotein concentration may be of value in the early
identification of tumors in pediatric candidates for transplantation.
