A longitudinal study of the relationship of plasma somatomedin-C concentration to the pubertal growth spurt
J. F. Cara, R. L. Rosenfield and R. W. Furlanetto
Cross-sectional studies from our institutions (Wyler Children's Hospital,
Chicago, and Children's Hospital of Philadelphia) and others have shown
that plasma somatomedin-C (Sm-C) concentrations rise during puberty. To
determine the relationship between rising plasma Sm-C levels and the growth
spurt at puberty, we undertook a longitudinal study of 11- to 18-year-old
children. Twelve male and eight female subjects were followed up on a
yearly basis for two to seven years (mean, 4.4 years). Height velocity,
plasma Sm-C concentrations, and stage of sexual development were determined
during each visit. All patients progressed normally in puberty during the
study. The plasma Sm-C level rose during early puberty in each child and
reached a maximal level of at least 2 U/mL In midpuberty, approximately one
year after the attainment of peak height velocity. Maximal plasma
concentrations of Sm-C were similar in male (3.5 +/- 0.71, mean +/- SEM)
and female (3.5 +/- 1.46) subjects. Plasma Sm-C levels subsequently
decreased slowly but remained above normal adult values for as long as four
years after peak height velocity was reached. Plasma Sm-C concentrations
increased steadily with increasing height velocity until peak height
velocity was attained with a mean rise of approximately 0.5 U for each
centimeter per year increase in height velocity. Since Sm-C levels remained
elevated while height velocity decreased, there was no significant
correlation between Sm-C levels and height velocity throughout puberty.
These results suggest that caution is required in interpreting Sm-C
concentrations during puberty; while normal pubertal levels may be in the
acromegalic range for adults, a plasma Sm-C level of less than 1 U/mL in
early puberty or less than 1.5 U/mL during middle to late puberty must be
considered subnormal.
Bone Metabolism in Adolescent Boys with Anorexia Nervosa
Misra et al.
J. Clin. Endocrinol. Metab. 2008;93:3029-3036.
ABSTRACT
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Lower growth hormone and higher cortisol are associated with greater visceral adiposity, intramyocellular lipids, and insulin resistance in overweight girls
Misra et al.
Am. J. Physiol. Endocrinol. Metab. 2008;295:E385-E392.
ABSTRACT
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Bone Metabolism in Adolescent Athletes With Amenorrhea, Athletes With Eumenorrhea, and Control Subjects
Christo et al.
Pediatrics 2008;121:1127-1136.
ABSTRACT
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Growth Hormone Suppression after an Oral Glucose Load in Children
Misra et al.
J. Clin. Endocrinol. Metab. 2007;92:4623-4629.
ABSTRACT
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Correlation Between Serum Levels of Insulin-like Growth Factor 1, Dehydroepiandrosterone Sulfate, and Dihydrotestosterone and Acne Lesion Counts in Adult Women
Cappel et al.
Arch Dermatol 2005;141:333-338.
ABSTRACT
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Augmentation of Growth Hormone Secretion after Testosterone Treatment in Boys with Constitutional Delay of Growth and Adolescence: Evidence against an Increase in Hypothalamic Secretion of Growth Hormone-Releasing Hormone
Racine et al.
J. Clin. Endocrinol. Metab. 2004;89:3326-3331.
ABSTRACT
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Growth Hormone and Ghrelin Responses to an Oral Glucose Load in Adolescent Girls with Anorexia Nervosa and Controls
Misra et al.
J. Clin. Endocrinol. Metab. 2004;89:1605-1612.
ABSTRACT
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Alterations in Growth Hormone Secretory Dynamics in Adolescent Girls with Anorexia Nervosa and Effects on Bone Metabolism
Misra et al.
J. Clin. Endocrinol. Metab. 2003;88:5615-5623.
ABSTRACT
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Growth Hormone and Insulin-Like Growth Factors Have Different Effects on Sebaceous Cell Growth and Differentiation
Deplewski and Rosenfield
Endocrinology 1999;140:4089-4094.
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Maturation of the Regulation of Growth Hormone Secretion in Young Males with Hypogonadotropic Hypogonadism Pharmacologically Exposed to Progressive Increments in Serum Testosterone
Giustina et al.
J. Clin. Endocrinol. Metab. 1997;82:1210-1219.
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