 |
|
Growth and Phosphorus Metabolism in Premature Infants Fed Human Milk, Fortified Human Milk, or Special Premature FormulaUse of Serum Procollagen as a Marker of Growth
Dennis E. Carey, MD;
Jonelle C. Rowe, MD;
Cynthia A. Goetz, RN;
Eva Horak, PhD;
Richard M. Clark, PhD;
Burton Goldberg, MD
Am J Dis Child. 1987;141(5):511-515.
Abstract
• Human milk promotes less than optimal growth and is associated with phosphorus deficiency and decreased bone mineralization in very-low-birth-weight (VLBW) infants. In this study, the effects of feeding premature infants either human milk (HM), fortified human milk (FHM), or special premature formula (Similac Special Care [SSC]) on growth, phosphorus metabolism, and serum type I procollagen (pColl-I-C) were evaluated. Infants fed FHM exhibited a rate of weight gain and an increase in head circumference comparable with infants fed SSC and significantly greater than infants fed HM, despite the fact that both the FHM group and the HM group demonstrated biochemical evidence of phosphorus deficiency. The pColl-I-C concentrations in VLBW infants were tenfold to 20-fold greater than concentrations in normal children older than 2 years of age. The pColl-I-C levels correlated positively with weight gain and Were significantly greater in the FHM and SSC groups than in the HM group. By contrast, serum alkaline phosphatase levels did not correlate with weight gain and were significantly lower in the rapidly growing SSC group than in either of the two groups with phosphorus deficiency and presumed poor bone mineralization. We conclude that the serum pColl-I-C concentration is a biochemical marker of growth in VLBW infants and may prove useful as a predictor of growth responses to various nutritional and therapeutic interventions.
(AJDC 1987;141:511-515)
Author Affiliations
From the Departments of Pediatrics (Drs Carey and Rowe and Ms Goetz) and Laboratory Medicine (Dr Horak), University of Connecticut Health Center, Farmington; the Department of Pediatrics, Newington (Conn) Children's Hospital (Dr Carey); the Department of Nutritional Sciences, University of Connecticut, Storrs (Dr Clark); and the Department of Pathology, University of Wisconsin, Madison (Dr Goldberg).
Footnotes
Accepted for publication Nov 4, 1986.
Read in part before the Society of Pediatric Research, San Francisco, May 4, 1984.
Reprint requests to Department of Pediatrics, University of Connecticut Health Center, Farmington, CT 06032 (Dr Carey).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review
McGuire and Anthony
Arch. Dis. Child. Fetal Neonatal Ed. 2003;88:F11-14.
ABSTRACT
| FULL TEXT
Feeding issues in preterm infants
COOKE and EMBLETON
Arch. Dis. Child. Fetal Neonatal Ed. 2000;83:F215-F218.
FULL TEXT
|
