This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

I. Interpatient and Intrapatient Theophylline Clearance Variability

Gerald B. Kolski, MD, PhD; Jacov Levy, MD; Robert Anolik, MD

Am J Dis Child. 1987;141(3):282-287.

Abstract
• A group of 167 pediatric asthmatics were followed up over four years, and their theophylline clearance values were recorded when they were admitted for status asthmaticus. A slow and gradual decrease of the clearance value was noted in all age groups. The clearance did not change significantly between the ages of 2 and 9 years. Longitudinal intrapatient clearance changes achieved statistical significance after the age of 9 years. When the patient groups were studied according to their initial clearance values, it became evident that only the patients with clearance values of 80 mL/kg/h showed significant changes of this value. In our patient group, obesity did not play a significant role in effecting a change in theophylline clearance.

(AJDC 1987;141:282-287)

Author Affiliations
From the Division of Allergy-Immunology-Pulmonology and Bone Marrow Transplantation, Children's Hospital of Philadelphia, and the Department of Pediatrics, University of Pennsylvania, Philadelphia.

Footnotes
Accepted for publication Oct 6, 1986.

Reprint requests to Pediatrician in Chief, Mary Imogene Bassett Hospital, Cooperstown, NY 13326-1394 (Dr Kolski).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?