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Morris Cohen, MBBCh; Arye Rubinstein, MD; John K. Li, MD; Gerald Nathenson, MD

Am J Dis Child. 1987;141(3):263-266.

Abstract
• A newborn had isotretinoin embryopathy, including thymic hypoplasia. Evaluation of her immune functions demonstrated progressive attrition of T cells over the nine weeks until her death due to pneumonia. These studies strongly suggest an insult by isotretinoin to the immune system. Immune abnormalities may predispose infants with isotretinoin embryopathy to infection and contribute to their high mortality.

(AJDC 1987;141:263-266)

Author Affiliations
From the Division of Neonatology, Department of Pediatrics (Drs Cohen and Nathenson), the Division of Allergy and Immunology (Dr Rubinstein), and the Department of Pathology (Dr Li), Albert Einstein College of Medicine, North Central Bronx Hospital, and Montefiore Medical Center. Dr Cohen is now with Newark (NJ) Beth Israel Medical Center.

Footnotes
Accepted for publication July 25, 1986.

Reprint requests to Division of Neonatology, Newark Beth Israel Medical Center, 201 Lyons Ave, Newark, NJ 07112 (Dr Cohen).

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