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Rotavirus GastroenteritisClinical and Laboratory Features and Use of the Rotazyme Test
Andrea Kovacs, MD;
Linda Chan, PhD;
Chiraporn Hotrakitya, MD;
Gary Overturf, MD;
Bernard Portnoy, MD
Am J Dis Child. 1987;141(2):161-166.
Abstract
• Clinical and laboratory features of 86 infants admitted with diarrhea and dehydration were evaluated prospectively. Human rotavirus (HRV) infection was documented in 35 infants (41%) by the Rotazyme test. Those with HRV gastroenteritis (HRV+ group) had a shorter duration of diarrhea prior to admission, more severe dehydration on presentation, and a longer hospital course than the HRV-negative (HRV-) group. Vomiting, fever, upper respiratory tract symptoms, otitis media, and cough were present in equal numbers of infants in both groups. The HRV+ infants had lower serum bicarbonate and higher serum albumin, alanine aminotransferase, aspartate aminotransferase, and uric acid concentrations than did the HRV- infants. Serum uric acid levels greater than 10 mg/dL (590 µmol/L) were present in 69% of HRV+ vs 29% of HRV–infants. The Rotazyme test was found to be a valuable tool in diagnosis; testing on two days increased the yield from 74% to 97% of all infants finally diagnosed as HRV+. The optimal time for testing was within the first five days of illness.
(AJDC 1987;141:161-166)
Author Affiliations
From the Department of Pediatrics, Los Angeles County–University of Southern California Medical Center and the University of Southern California School of Medicine, Los Angeles. Dr Kovacs is now also affiliated with the Department of Pediatrics, City of Hope National Medical Center, Duarte, Calif.
Footnotes
Accepted for publication Aug 25, 1986.
Read in part before the Western Society for Pediatric Research, Carmel, Calif, Feb 6, 1985.
Reprint requests to Department of Pediatrics, City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010 (Dr Kovacs).
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