Congenital ocular blindness in children, 1945 to 1984
G. C. Robinson, J. E. Jan and C. Kinnis
Department of Pediatrics, Faculty of Medicine, B.C. Children's Hospital, Vancouver, Canada.
A total of 676 children born in British Columbia with congenital ocular
blindness during the years 1945 through 1984 were studied. The birth
prevalence rate of congenital blindness has decreased from eight per 10,000
live births in the late 1940s to three per 10,000 live births. Retinopathy
of prematurity was replaced by genetic ocular disorders as the leading
cause of congenital blindness, although the former is reemerging. The rate
of congenital rubella infection also declined. There has been a significant
increase in the rate of births with optic nerve lesions during the past 15
years, while the rate of births with lesions of the lens fell, reflecting
the decline in the rate of maternal rubella infection. There are fewer
children with congenital ocular legal blindness who have no light
perception today, and they also have fewer associated handicaps.
Recent trends in visual impairment and blindness in the UK
Bodeau-Livinec et al.
Arch. Dis. Child. 2007;92:1099-1104.
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The zebrafish cornea: structure and development.
Zhao et al.
IOVS 2006;47:4341-4348.
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Mutations in {beta}B3-Crystallin Associated with Autosomal Recessive Cataract in Two Pakistani Families
Riazuddin et al.
IOVS 2005;46:2100-2106.
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A New Locus for Autosomal Recessive Nuclear Cataract Mapped to Chromosome 19q13 in a Pakistani Family
Riazuddin et al.
IOVS 2005;46:623-626.
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A Homozygous Splice Mutation in the HSF4 Gene Is Associated with an Autosomal Recessive Congenital Cataract
Smaoui et al.
IOVS 2004;45:2716-2721.
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A Nonsense Mutation in the Glucosaminyl (N-acetyl) Transferase 2 Gene (GCNT2): Association with Autosomal Recessive Congenital Cataracts
Pras et al.
IOVS 2004;45:1940-1945.
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Visual impairment and blindness in Europe and their prevention
Kocur and Resnikoff
Br. J. Ophthalmol. 2002;86:716-722.
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Cortically visually impaired children: a need for more study
HOYT and FREDRICK
Br. J. Ophthalmol. 1998;82:1225-1227.
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