This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Tatiana M. Doberczak, MD; John C. Thornton, PhD; Jonine Bernstein, MS; Stephen R. Kandall, MD

Am J Dis Child. 1987;141(11):1163-1167.

Abstract
• The impact of maternal opiate dependency on birth weight and head circumference of offspring was studied in 150 mother-infant pairs and 150 controls. Mean birth weight and head circumference of drug-dependent offspring were reduced symmetrically compared with drug-free controls of similar socioeconomic status. Although mean gestational ages and rates of prematurity were similar, intrauterine growth retardation occurred in 20% of passively addicted infants vs 4% of controls. A longer period of methadone maintenance was associated with longer gestation and increased birth weight, while higher methadone dosages were associated with higher birth weights and larger head circumferences. Smoking was associated with reduced birth weight by an average of 160 g per pack of cigarettes smoked per day; longer duration of smoking was associated with reductions in both birth weight and head circumference. These data suggest therapeutic strategies to improve these fetal growth characteristics and perhaps improve neurobehavioral outcome of drug-dependent newborns.

(AJDC 1987;141:1163-1167)

Author Affiliations
From the Departments of Pediatrics (Drs Doberczak and Kandall) and Biomathematics (Dr Thornton and Ms Bernstein), Beth Israel Medical Center, Mt Sinai School of Medicine, New York.

Footnotes
Accepted for publication July 6, 1987.

Presented in part before the New York Perinatal Society, New York, May 30, 1984.

Reprint requests to Beth Israel Medical Center, First Avenue at 16th Street, New York, NY 10003 (Dr Kandall).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Fentanyl Transdermal Analgesia During Pregnancy and Lactation
Cohen
J Hum Lact 2009;25:359-361.
ABSTRACT  

The Maternal Lifestyle Study: Drug Use by Meconium Toxicology and Maternal Self-Report
Lester et al.
Pediatrics 2001;107:309-317.
ABSTRACT | FULL TEXT  

Dose-Response Effect of Cocaine on Newborn Head Circumference
Bateman and Chiriboga
Pediatrics 2000;106:33e-33.
ABSTRACT | FULL TEXT