This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Gary Francis, MD, PhD; William Riley, MD

Am J Dis Child. 1987;141(10):1081-1083.

Abstract
• Three patients demonstrated transient neonatal hypothyroidism, presumably secondary to maternally derived thyrotropin (TSH)–blocking antibodies. Although transient, this disorder might not have been benign in the first child, who exhibited significant developmental delay. A thyroid scan was not helpful in making this diagnosis. Although uncommon, this disorder should be suspected in infants with a maternal history of autoimmune autoimmune thyroid disease, multiple siblings with congenital hypothyroidism, or a clinical course characterized by continually suppressed TSH levels, despite low doses of levothyroxine sodium replacement. Measurement of TSH-blocking antibodies may be used in the diagnosis of transient neonatal hypothyroidism at birth and is becoming more readily available from reference laboratories. Once diagnosed, the patient may then be prepared for monitored withdrawal of levothyroxine replacement therapy at 2 to 3 years of age and Will not be committed to lifelong replacement therapy.

(AJDC 1987;141:1081-1083)

Author Affiliations
From the Department of Pediatrics, Wuesthoff Memorial Hospital, Rockledge, Fla (Dr Francis); andnd the Departments of Pathology and Pediatrics, University of Florida, Gainesville (Dr Riley). Dr Francis is now with the Department of Pediatrics, Dwight David Eisenhower Army Medical Center, Fort Gordon, Ga.

Footnotes
Accepted for publication March 4, 1987.

Presented at the Second Joint Meeting of the Lawson Wilkins Society and European Society for Pediatric Endocrinology, Baltimore, June 22, 1985.

The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

Reprint requests to Department of Pathology, University of Florida, Gainesville, FL 32610 (Dr Riley).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Sensory Neuron Sodium Current Requires Nongenomic Actions of Thyroid Hormone During Development
Yonkers and Ribera
J. Neurophysiol. 2008;100:2719-2725.
ABSTRACT | FULL TEXT