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Kathie Brandenburg, RN, MS; Amos S. Deinard, MD, MPH; Joan DiNapoli, RN, PhD; Steven J. Englender, MD, MPH; Joseph Orthoefer, DVM, MPH; Doris Wagner, RN, MS

Am J Dis Child. 1986;140(9):894-896.

Abstract
• The therapeutic efficacy and tolerance of a single application of 1% permethrin cream rinse, applied for ten minutes, and a single application of 1% lindane shampoo applied, as recommended by the manufacturer, for four minutes, against the head louse Pediculus humanus var capitis were compared in a single-blinded, randomized, controlled clinical trial. Of 573 patients enrolled at eight centers, 559 were assessable for tolerance and 508 for efficacy. Of the 257 patients treated with 1% permethrin cream rinse, 99% were lice free at 14 days; of the 251 patients treated with 1% lindane shampoo, 85% were lice free at 14 days. The difference is statistically significant. For both treatments, adverse experiences were infrequent, mild, and usually difficult to distinguish from the symptoms of head lice infestation. A single ten-minute application of 1% permethrin cream rinse was well tolerated, highly effective, and therapeutically superior to a single four-minute application of 1% lindane shampoo.

(AJDC 1986;140:894-896)

Author Affiliations
From the City of Nashua (NH) Community Health Department (Ms Brandenburg); Bureau of Maternal and Child Health, Minneapolis Health Department, and Department of Pediatrics, University of Minnesota, Minneapolis (Dr Deinard); Consultation and Research Inc, Durham, NC (Dr DiNapoli); Maricopa County Department of Health Services, Phoenix (Dr Englender); Winnebago County Department of Public Health, Rockford, Ill (Dr Orthoefer); and Marion County Health Department, Indianapolis (Ms Wagner). Dr Englender is now with the Arizona Department of Health Services, Phoenix.

Footnotes
Accepted for publication June 3, 1986.

Reprint requests to Box 85, University of Minnesota Hospital, Minneapolis, MN 55455 (Dr Deinard).

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