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The Role of Bilirubin Production

John D. Johnson, MD; Pamela Angelus, RN; Marilyn Aldrich, RN; Betty J. Skipper, PhD

Am J Dis Child. 1986;140(9):889-890.

Abstract
• We have explored further the mechanism of exaggerated neonatal hyperbilirubinemia in the Navajo by determining bilirubin production rates with measurements of endogenous carbon monoxide excretion. Navajo newborns had elevated serum bilirubin concentrations and endogenous carbon monoxide excretion measurements at 2 days of age compared with a Caucasian control population. These findings could not be explained by differences in gestational age, postnatal age, or hemoglobin concentration. We conclude that accentuated bilirubinemia in Navajo neonates is partially due to increased bilirubin production.

(AJDC 1986;140:889-890)

Author Affiliations
From the Departments of Pediatrics (Dr Johnson and Mss Angelus and Aldrich) and Family, Emergency, and Community Medicine (Dr Skipper), University of New Mexico School of Medicine, Albuquerque.

Footnotes
Accepted for publication May 21, 1986.

Reprint requests to Department of Pediatrics, University of New Mexico School of Medicine, Albuquerque, NM 87131 (Dr Johnson).

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