This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Karen Lewis, MD; James D. Cherry, MD; H. James Holroyd, MD; Leonard R. Baker, MD; Frank E. Dudenhoeffer, MD; Ricki G. Robinson, MD

Am J Dis Child. 1986;140(9):872-876.

Abstract
• An acellular pertussis—component diphtheria-tetanus-pertussis (AC-DTP) vaccine was compared with a currently licensed, whole-cell pertussis—component DTP (WC-DTP) vaccine for reactogenicity and immunogenicity when given as the fourth DTP immunization in sixty 18- to 24-month-old children. Reactions over the first 48 hours were significantly less common in the AC-DTP vaccine recipients, as follows (WC-DTP/AC-DTP): fever, 85%/5%; redness, 70%/12.5%; tenderness, 100%/22.5%; swelling, 35%/10%; fretfulness, 70%/12.5%; anorexia, 35%/2.5%; and vomiting, 10%/0%. Antibody responses to pertussis antigens (agglutinogens, lymphocytosis-promoting factor, and filamentous hemagglutinin), diphtheria toxoid, and tetanus toxoid in AC-DTP vaccine recipients were comparable with those in WC-DTP vaccine recipients. The AC-DTP vaccine evaluated in this trial seems to be as immunogenic as WC-DTP vaccine while being markedly less reactogenic.

(AJDC 1986;140:872-876)

Author Affiliations
From the Department of Pediatrics, UCLA School of Medicine, Center for the Health Sciences (Drs Lewis and Cherry); and the Descanso Pediatric Medical Group, LaCanada, Calif (Drs Holroyd, Baker, Dudenhoeffer, and Robinson).

Footnotes
Accepted for publication June 23, 1986.

Presented at the Western Society for Pediatric Research, Carmel, Calif, Feb 7, 1986; and at the Society for Pediatric Research, Washington, DC, May 7, 1986.

Reprint requests to Department of Pediatrics, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, CA 90024 (Dr Cherry).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A Comparative Efficacy Trial in Germany in Infants Who Received Either the Lederle/Takeda Acellular Pertussis Component DTP (DTaP) Vaccine, the Lederle Whole-Cell Component DTP Vaccine, or DT Vaccine
Stehr et al.
Pediatrics 1998;101:1-11.
ABSTRACT | FULL TEXT