Nonimmune hydrops fetalis in Noonan's syndrome
E. V. Bawle and V. Black
Nonimmune hydrops fetalis has been reported to be associated with
congenital malformations. We describe two newborns with Noonan's syndrome
who presented with nonimmune hydrops fetalis that was most likely secondary
to a generalized lymphatic vessel dysplasia. Other manifestations of
lymphatic abnormalities in Noonan's syndrome, such as pedal edema and
pulmonary and intestinal lymphangiectasis, have been observed in children.
Nonimmune hydrops represents one end of the spectrum of abnormalities seen
in this syndrome.
