Human T-cell lymphotropic virus type III (HTLV-III) embryopathy. A new dysmorphic syndrome associated with intrauterine HTLV-III infection
R. W. Marion, A. A. Wiznia, G. Hutcheon and A. Rubinstein
Twenty infants and children with positive serologic tests for the human
T-cell lymphotropic virus type III (HTLV-III) were noted to have similar
features including growth failure (75%), microcephaly (70%), and
craniofacial abnormalities consisting of ocular hypertelorism (50%);
prominent box-like appearance of the forehead (75%); flat nasal bridge
(70%); mild upward or downward obliquity of the eyes (65%); long palpebral
fissures with blue sclerae (60%); short nose with flattened columella and
well-formed, triangular philtrum (65%); and patulous lips (60%). These
features constitute a new and distinct dysmorphic syndrome, the HTLV-III
embryopathy.
