Restoration of suppressor T-cell functions in children with AIDS following intravenous gamma globulin treatment
A. Gupta, B. E. Novick and A. Rubinstein
Suppressor T-cell function was analyzed in seven children with acquired
autoimmunodeficiency syndrome (AIDS) or AIDS-related complex (ARC). Four of
the patients had markedly increased serum IgG levels. All patients had
elevated percentages and absolute numbers of peripheral blood T8 cells. In
vitro concanavalin A generation of suppressor cells for T-cell mitogenic
responses and suppression of pokeweed mitogen-driven immunoglobulin
secretion were diminished in all patients. After intravenous treatment with
gamma globulin, four patients regained in vitro suppression of pokeweed
mitogen-driven gamma globulin secretion. Treatment with intravenous gamma
globulin also modified in vitro suppressor T-cell functions in children
with AIDS or ARC.
