Antibody response to pneumococcal vaccine in children aged 5 to 15 years
J. C. Paton, I. R. Toogood, R. A. Cockington and D. Hansman
The type-specific antibody response of 99 healthy children, aged 5 to 15
years, to a 14-valent pneumococcal vaccine was determined and analyzed
according to age at the time of vaccination. The response to the majority
of the serotypes, including the important "pediatric" types 6A, 18C, and
19F, appeared to plateau in the 8- to 10-year-old age group, whereas for
types 14 and 23F, which are also important in children, the response
continued to improve with age to ages 13 to 15 years. The antibody response
of a group of 23 children, aged 5 to 15 years, with various hematologic
disorders (12 of whom had undergone splenectomy) was also determined and
compared with that of the healthy children. For all serotypes the antibody
response was similar in the two groups.
