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Reye's SyndromeAn Epidemiologic Analysis of Mild Disease
Francis J. Holtzhauer, MS;
Robert J. Campbell, MS;
Lois J. Hall, MS;
Thomas J. Halpin, MD, MPH
Am J Dis Child. 1986;140(12):1231-1236.
Abstract
• Patients with Reye's syndrome (RS) whose degree of severity was classified as stage 0 (alert and awake) were compared with patients with a severity classification of stage 1 or greater. The centers for Disease Control case definition and staging criteria were used. Two hundred twenty-seven patients with RS were investigated by the Ohio Department of Health from Dec 1, 1978, through March 31, 1980. There were 67 identified patients who never exceeded stage 0 and 160 patients classified as stage 1 or greater. Both groups of patients were compared according to demographic features, symptomatology, medication use during the antecedent illness, and laboratory findings during the RS illness. Stage 0 patients were similar to patients at stage 1 or greater in their demographic features, illnesses, medications preceding RS, and results of liver function tests; however, values of serum ammonia, creatine phosphokinase, prothrombin time, and bilirubin increased with RS severity.
(AJDC 1986;140:1231-1236.
Author Affiliations
From the Ohio Department of Health, Bureau of Preventive Medicine, Columbus.
Footnotes
Accepted for publication April 28, 1986.
Reprint requests to Bureau of Preventive Medicine, Ohio Department of Health, PO Box 118, Columbus, OH 43216 (Mr Holtzhauer).
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