Thyrotropin binding inhibitor immunoglobulin. Its pathogenetic importance in hypothyroidism
O. Arisaka, M. Arisaka, Y. Nakayama, N. Shimura, K. Obinata, T. Ino, S. Niijima, T. Akiyama, K. Yabuta, K. Arikawa and al. et
Two patients with hypothyroidism had detectable serum levels of thyrotropin
binding inhibitor immunoglobulin (TBII). Patient 1 was a newborn infant who
had transient neonatal hypothyroidism due to transfer of TBII from the
mother with nongoitrous autoimmune thyroiditis. Patient 2 was an 8-year-old
girl with Down's syndrome who presented with signs of myxedema and central
precocious puberty. She had no goiter, and the recognition of thyroid
disease was delayed; the histological diagnosis of chronic lymphocytic
thyroiditis was established by aspiration biopsy, and TBII had strong
thyroid adenyl cyclase-inhibiting activity in vitro. It appears that TBII
may be pathogenetically important for occurrence of neonatal hypothyroidism
and nongoitrous autoimmune thyroiditis without goiter.
