Second malignant neoplasm in treated Hodgkin's disease. Report of a patient and scope of the problem
Y. Takaue, M. P. Sullivan, I. Ramirez, K. R. Cleary and J. van Eys
The condition of a 6-year-old boy was diagnosed as mixed-cellularity
Hodgkin's disease that involved the right side of the neck. Five years
after the completion of radiation therapy for the involved area, followed
by six courses of chemotherapy with mechlorethamine hydrochloride (nitrogen
mustard), vincristine sulfate, procarbazine hydrochloride, and prednisone,
he developed cerebral gliosarcoma. Numerous second malignant neoplasms have
been reported in adults following treatment for Hodgkin's disease; however,
the sequence of events in our patient is a new finding that has not, to our
knowledge, been reported previously. While the second malignant tumor may
have been induced by prior treatment, direct evidence is lacking.
