Parainfluenza Virus Bronchiolitis: Epidemiology and Pathogenesis

doi:10.1001/archpedi.1986.02140150036029

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Vol. 140 No. 1, January 1986

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Parainfluenza Virus Bronchiolitis

Epidemiology and Pathogenesis

Robert C. Welliver, MD; David T. Wong, MD; Martha Sun; Nancy McCarthy, RN

Am J Dis Child. 1986;140(1):34-40.

Abstract

• An investigation of the epidemiology and pathogenesisof bronchiolitis due to parainfluenza virus (PV) was carriedout. Bronchiolitis due to PV occurred most commonly in non-Caucasianmales. Breast-fed infants exhibited a reduced risk of developingbronchiolitis. Once an episode of PV bronchiolitis occurred,both exposure to cigarette smoke and bottle feeding were associatedwith an increased frequency of recurrent wheezing, and subsequentinfection with respiratory virus almost uniformly resulted inwheezing. Cell-mediated immune responses to PV antigen and titersof PV-specific IgE were greater among patients with bronchiolitisthan among patients with upper respiratory tract infection.The epidemiology and pathogenesis of bronchiolitis due to PVis similar to that of respiratory syncytial virus. Lower respiratorytract infection may predispose to episodes of bronchoconstrictionon subsequent exposure to cigarette smoke or other viral infections.

(AJDC 1986;140:34-40)

Author Affiliations

From the Department of Pediatrics, School of Medicine, State University of New York at Buffalo (Drs Welliver and Wong), and the Division of Infectious Diseases, Children's Hospital of Buffalo (Drs Welliver and Wong and Mss Sun and McCarthy).

Footnotes

Accepted for publication Oct 3, 1985.

Reprint requests to Division of Infectious Diseases, Children'sHospital of Buffalo, 219 Bryant St, Buffalo, NY 14222 (Dr Welliver).

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