This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Correlation of Drug-Susceptibility Patterns of Matched Patient and Source Case Strains of Mycobacterium tuberculosis

Phillip Steiner, MD; Madu Rao, MD; Milicent Mitchell, MD; Morris Steiner, MD

Am J Dis Child. 1985;139(8):780-782.

Abstract
• The purpose of this study is to compare the drug-susceptibility patterns of Mycobacterium tuberculosis isolated from patients (children) and from their corresponding adult contacts. We wished to ascertain if the susceptibility pattern of the isolate from the adult contact could be used as a guide in the initial selection of the antituberculous drug regimen in the child. Strains resistant to one or more antituberculous drugs were emphasized in our study. For 120 children with positive cultures, adults were identified who had positive cultures and who were the source of the children's infections. All strains had susceptibility tests for isoniazid, streptomycin, aminosalicylic acid, ethionamide, and, when they became available, ethambutol and rifampin. There were 29 instances in which either the adult's and/or the child's strain were resistant to one or more antituberculous drugs. In 111 (92.5%) instances the organism isolated from the child and that from the adult contact had identical drug-susceptibility patterns. Fourteen (93%) of 15 of the adult/child pairs were both resistant to isoniazid. The drug-susceptibility pattern of isolates obtained from the source of a child's illness is useful as a guide in planning initial drug therapy. In addition, knowledge of isoniazid-resistant strains in adult contacts may alert the physician to the potential failure of isoniazid prophylaxis.

(AJDC 1985;139:780-782)

Author Affiliations
From the Department of Pediatrics, State University of New York, Downstate Medical Center, Brooklyn.

Footnotes
Reprint requests to Department of Pediatrics, Downstate Medical Center, 450 Clarkson Ave, Box 49, Brooklyn, NY 11203 (Dr P. Steiner).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Community-based therapy for children with multidrug-resistant tuberculosis.
Drobac et al.
Pediatrics 2006;117:2022-2029.
ABSTRACT | FULL TEXT  

Culture confirmed multidrug resistant tuberculosis: diagnostic delay, clinical features, and outcome
Schaaf et al.
Arch. Dis. Child. 2003;88:1106-1111.
ABSTRACT | FULL TEXT