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A Longitudinal Study

Jane Eisenhaure O'Brien, MD; Murray Feingold, MD

Am J Dis Child. 1985;139(7):711-712.

Abstract
• We descibe 15 patients with incontinentia pigmenti whom we have followed up from two to 11 years. This longitudinal approach allowed us to observe the course of the skin lesions and developmental progress of these children. We found that in contrast to what has been previously reported in most of the literature, the bullous and verrucous lesions do not always resolve during the first or second year of life and may recur throughout childhood. Although most patients with incontinentia pigmenti are of normal intelligence, those with neonatal seizures have a poor prognosis for normal development.

(AJDC 1985;139:711-712)

Author Affiliations
From the Department of Birth Defects and Genetics, Kennedy Memorial Hospital, Brighton, Mass.

Footnotes
Reprint requests to The National Birth Defects Center, 30 Warren St, Brighton, MA 02135 (Dr Feingold).

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