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A Clinicopathologic and Immunocytochemical Study

Michael D. Whitaker, MD; Bernd W. Scheithauer, MD; Alvin B. Hayles, MD; Haruo Okazaki, MD

Am J Dis Child. 1985;139(7):679-682.

Abstract
• Cerebral glgantism, or Sotos' disease, is a rare disorder of unknown cause characterized by the early onset of excessive growth, acromegallc features, and some degree of mental retardation. Although several endocrinologic abnormalities have been described in such patients, none has been specific or sufficient to explain the clinical features. Our report of the endocrinologic and pathologic aspects in a young woman with Sotos' disease includes the first microanatomic study of the hypothalamus and Immunocytochemical examination of the pituitary gland in this disorder.

(AJDC 1985;139:679-682)

Author Affiliations
From the Division of Endocrinology, Metabolism, and Internal Medicine (Drs Whitaker and Hayles), and the Departments of Pathology (Drs Scheithauer and Okazaki) and Pediatrics (Dr Hayles), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Footnotes
Reprint requests to Department of Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Dr Scheithauer).

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