Oral glucose-electrolyte solutions as maintenance therapy of acute diarrhea
R. Listernick, E. Zieserl and A. T. Davis
Sixty well-nourished, well-hydrated infants, 3 to 24 months of age with
uncomplicated acute gastroenteritis, were enrolled in a prospective,
randomized, double-blind study that compared the safety and efficacy of two
oral solutions. The solutions differed primarily in the sodium
concentration (60 v 30 mEq/L) and glucose concentration (2% v 5%). The mean
serum sodium concentrations of the two groups did not differ significantly
from each other at entry or at the end of the study period. In addition,
there were no significant changes in the mean serum sodium concentration
within each group at the end of the study period. No child in either group
became hypernatremic. Our results indicate that a solution with a high
concentration of sodium initially designed for the rehydration of
dehydrated children also can be safely and effectively used as a
maintenance solution for the treatment of well-hydrated children older than
3 months of age with acute gastroenteritis.
