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Preliminary Observations

Sheela G. Laungani, MD; Barbara Delivoria, MD; Alan Gintzler, PhD; Shing Wong, BPS; Leonard Glass, MD

Am J Dis Child. 1985;139(4):403-404.

Abstract
• β-Endorphinlike immunoreactivity (BLI) was measured in sterile, bloodless samples of cerebrospinal fluid (CSF) during the first 24 hours of life in order to assess the relationship between perinatal asphyxia and endogenous opioid activity within the central nervous system. The median CSF BLI in infants with one-minute Apgar scores of 1 to 4 was 148 pg/mL (range, 96 to 171 pg/mL) and that of infants with Apgar scores of 5 to 9 was 78 pg/mL (range, 25 to 162 pg/mL). The linear regression equation correlating CSF BLI with one-minute Apgar score was y= –10.7x+169.1. Our findings of a highly significant inverse correlation between one-minute Apgar scores and CSF BLI support the hypothesis that perinatal asphyxia is associated with increased activity of opioid systems in the central nervous system.

(AJDC 1985;139:403-404)

Author Affiliations
From the Departments of Pediatrics (Drs Laungani, Delivoria, and Glass and Mr Wong) and Biochemistry (Dr Gintzler), State University of New York, Downstate Medical Center, Brooklyn.

Footnotes
Read in part before the annual meeting of the Society for Pediatric Research, San Francisco, May 1, 1984.

Reprint requests to Department of Pediatrics, Box 49, Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203 (Dr Glass).

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