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Implications for Hepatic Transplantation Programs

John D. Lloyd-Still, MD

Am J Dis Child. 1985;139(4):381-384.

Abstract
• Mortality from liver disease in a pediatric hospital was reviewed to assess the implications for hepatic transplantation programs. Between 1976 and 1983, 81 children died of hepatic failure that included biliary atresia (n = 20), metabolic disorders (n = 22), Reye's syndrome (n = 7), infections (n = 15), cholestatic syndromes (n = 12), and miscellaneous causes (n = 5). Hepatic failure was considered the secondary cause of death in only five patients. Acute hepatic failure was present in 42% (34/81) of patients, whereas 58% (47/81) had preexisting chronic liver disease. Forty (49.4%) of the 81 patients died in infancy, including two thirds of the patients with biliary atresia. Liver disease accounted for 6.6% (81/1,225) of all deaths in our hospital during this eight-year period. During this interval, eight patients (six alive) underwent liver transplantation. Approximately 2.9 patients per year will be candidates for liver transplantation.

(AJDC 1985;139:381-384)

Author Affiliations
From the Division of Gastroenterology, Department of Pediatrics, Children's Memorial Hospital, Northwestern University Medical School, Chicago.

Footnotes
Reprint requests to Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL 60614 (Dr Lloyd-Still).

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