This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Gertrude Costin, MD; A. Linn Murphree, MD

Am J Dis Child. 1985;139(3):249-254.

Abstract
• We studied the clinical characteristics and hypothalamic-pituitary function in 23 patients with optic nerve hypoplasia (ONH), 6 months to 19 years old. All patients had decreased visual acuity and small optic discs; the septum pellucidum was absent in five of 19. Nine of 11 patients had minor EEG abnormalities, and two had microcephaly. The height, weight, and growth rate were normal in all patients 6 months to 3 years old. Hypopituitarism was found in 15 patients. Fasting and stimulated prolactin levels and the area under the prolactin curve after thyrotropin releasing hormone were significantly greater than in controls and in patients with idiopathic hypopituitarism. These results associate ONH with a high incidence of hypopituitarism, hyperprolactinemia, and neurologic abnormalities. The normal growth in the absence of measurable growth hormone suggests that hyperprolactinemia may stimulate growth temporarily and that a normal height in childhood or the presence of the septum pellucidum do not exclude the possibility of hypopituitarism.

(AJDC 1985;139:249-254)

Author Affiliations
From the Departments of Pediatrics (Dr Costin) and Ophthalmology (Dr Murphree), University of Southern California School of Medicine, Los Angeles; and the Divisions of Endocrinology and Metabolism (Dr Costin) and Ophthalmology (Dr Murphree), Childrens Hospital of Los Angeles.

Footnotes
Read in part before the First Joint Meeting of the Pediatric Endocrine Society and the European Society for Pediatric Endocrinology, Geneva, Sept 10, 1981.

Reprint requests to Division of Endocrinology and Metabolism, 4650 Sunset Blvd, Los Angeles, CA 90027 (Dr Costin).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Endocrine Status in Patients with Optic Nerve Hypoplasia: Relationship to Midline Central Nervous System Abnormalities and Appearance of the Hypothalamic-Pituitary Axis on Magnetic Resonance Imaging
Birkebaek et al.
J. Clin. Endocrinol. Metab. 2003;88:5281-5286.
ABSTRACT | FULL TEXT  

Review Article: Optic Nerve Hypoplasia: A Review
Ouvrier and Billson
J Child Neurol 1986;1:181-188.
ABSTRACT