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A New Kindred With Variable Phenotypic Expression

Reuben Steinherz, MD; Yael Levy, MD; Aviva Litwin, MD; Menachem Nitzan, MD; Eva Friedman, MSc; Stanley Levin, MB, BCh

Am J Dis Child. 1985;139(2):191-193.

Abstract
• A kindred with five affected maternally related male members showed variable phenotypic expression of the X-linked lymphoproliferative syndrome. In one of the children, agammaglobulinemia developed following infectious mononucleosis. His brother had aplastic anemia in infancy and 2 years later died of overwhelming pneumonia resulting from ornithosis. A third brother died of reticulum cell sarcoma. Two maternally related male cousins died of reticulum cell sarcoma of the neck.

(AJDC 1985;139:191-193)

Author Affiliations
From the Department of Pediatrics A, Beilinson Medical Center, Petah Tiqva, Israel (Drs Steinherz, Levy, Litwin, and Nitzan and Ms Friedman), and the Department of Pediatrics A, Kaplan Hospital, Rehovot, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel (Dr Levin).

Footnotes
Reprint requests to Department of Pediatrics A, Biochemical and Developmental Genetic Unit, Beilinson Medical Center, Petah Tiqva, 49 100, Israel (Dr Steinherz).

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