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Jack Van Hoff, MD; A. Kim Ritchey, MD; Bennett A. Shaywitz, MD

Am J Dis Child. 1985;139(11):1120-1123.

Abstract
• We treated two children with sickle cell disease and intracranial hemorrhage. The incidence of intracranial hemorrhage is increased in sickle cell disease, although not as markedly as that of cerebral infarction. Intracranial hemorrhage has a higher mortality, a lower rate of permanent neurologic impairment, and occurs more often in older patients than does cerebral infarction. Intracranial hemorrhage in adults is likely to be an intracerebral hemorrhage or a subarachnoid hemorrhage secondary to an aneurysm. Children, however, are more likely to have subarachnoid hemorrhage without an identifiable aneurysm. We hypothesize that both hemorrhages and infarcts are due to large-vessel cerebral vasculopathy secondary to the abnormal rheologic features of sickled cells.

(AJDC 1985;139:1120-1123)

Author Affiliations
From the Divisions of Hematology-Oncology (Drs Van Hoff and Ritchey) and Neurology (Dr Shaywitz), Department of Pediatrics, Yale University School of Medicine, New Haven, Conn.

Footnotes
Reprint requests to Department of Pediatrics, Yale University School of Medicine, PO Box 3333, New Haven, CT 06510 (Dr Van Hoff).

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