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Treatment With Luteinizing Hormone Releasing Hormone Analogue

Louisa Laue, MD; Florence Comite, MD; Karen Hench, RN; D. Lynn Loriaux, MD, PhD; Gordon B. Cutler, Jr, MD; Ora Hirsch Pescovitz, MD

Am J Dis Child. 1985;139(11):1097-1100.

Abstract
• Seven children with central precocious puberty and either neurofibromatosis and/or optic gliomas were referred to the National Institutes of Health, Bethesda, Md, for evaluation and treatment with the long-acting luteinizing hormone releasing hormone analogue (LHRH_a) D-Trp⁶-Pro⁹-NEt-LHRH. Only six of the seven children chose to receive treatment. Four children presented with neurofibromatosis, three of whom also had optic gliomas; the remaining three children had isolated optic gliomas, without other neurocutaneous stigmas. All had central precocious puberty mediated by activation of the hypothalamic-pituitary-gonadal axis. Six months of LHRH_, therapy caused suppression of gonadotropin and sex steroid levels, stabilization or regression of secondary sexual characteristics, and decreases in growth velocity and the rate of bone age maturation. We conclude that LHRH_, therapy is effective in the treatment of central precocious puberty secondary to neurofibromatosis and/or optic gliomas.

(AJDC 1985;139:1097-1100)

Author Affiliations
From the Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md.

Footnotes
Reprint requests to National Institutes of Health, 9000 Rockville Pike, Bldg 10, Room 10N262, Bethesda, Md 20205 (Dr Laue).

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