 |
|
Penicillin-Intermediate Pneumococci in a Children's Hospital
Lynne D. Willett, MD;
Hugh C. Dillon, Jr, MD;
Barry M. Gray, MD
Am J Dis Child. 1985;139(10):1054-1057.
Abstract
| |
• During the three-year period from 1981 to 1984, all clinical isolates of Streptococcus pneumoniae were screened for resistance to penicillin in the clinical bacteriology laboratory at The Children's Hospital of Alabama, Birmingham. Twenty-eight of 828 isolates were presumed resistant by disk diffusion testing with 1-µg oxacillin disks (zone diameter, 20 mm). Seventeen of the 28 (61%) were found to be intermediately sensitive to penicillin by a conventional agar dilution method. Penicillin-intermediate strains had a minimal inhibitory concentration of 0.125 to 0.5 mg/L; no penicillin-resistant (minimal inhibitory concentration, >1 mg/L) strains were encountered. The prevalence of penicillin-intermediate strains was thus 17 of 828 isolates, or 2.1%. These strains were also examined for susceptibility to ampicillin, vancomycin, cefotaxime, and chloramphenicol. We present the clinical features of 17 patients with disease due to penicillin-intermediate pneumococci.
(AJDC 1985;139:1054-1057)
Author Affiliations
From the Departments of Pediatrics, University of Alabama at Birmingham and The Children's Hospital of Alabama, Birmingham (Drs Dillon and Gray), and University of Nebraska Medical Center, Omaha (Dr Willett).
Footnotes
Reprint requests to the Department of Pediatrics, University of Alabama at Birmingham, University Station, Birmingham, AL 35294 (Dr Gray).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Therapy for Children With Invasive Pneumococcal Infections
Committee on Infectious Diseases
Pediatrics 1997;99:289-299.
ABSTRACT
| FULL TEXT
Management of Infections Caused by Antibiotic-Resistant Streptococcus Pneumoniae
Friedland and McCracken
NEJM 1994;331:377-382.
FULL TEXT
|
