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Clinical Trial of a New Trivalent Measles-Mumps-Rubella Vaccine in Young Children
Timo Vesikari, MD;
Eija-Liisa Ala-Laurila, MD;
Anneli Heikkinen, MD;
Annikki Terho, MD;
Eric D'Hondt, MSc;
Francis E. André, MD
Am J Dis Child. 1984;138(9):843-847.
Abstract
• Trivalent measles-mumps-rubella virus vaccines, containing either Schwarz (two dosage levels), Urabe Am 9, and RA 27/3 strains or Moraten, Jeryl Lynn, and RA 27/3 strains, were evaluated in 174 children aged 14 to 24 months. Each of the three vaccines induced a nearly 100% seroconversion for measles and mumps and a full 100% seroconversion for rubella. Close home monitoring disclosed a high incidence and a relatively constant pattern of vaccine-associated reactions, similar for all three vaccines. Febrile reactions of greater than or equal to 39 °C between days 5 and 12 after vaccination were more frequent among the recipients of "high"-dose Schwarz strain vaccine (35%) than among the recipients of corresponding "low"-dose vaccine (23%) or the Moraten strain vaccine (13%). The Schwarz-Urabe Am 9-RA 27/3 was equally immunogenic and, with a low dose of measles virus, no more reactogenic than the Moraten-Jeryl Lynn RA 27/3 trivalent vaccine.
(AJDC 1984;138:843-847)
Author Affiliations
From the Department of Clinical Sciences, University of Tampere (Dr Vesikari), the Health Care Center of the City of Tampere (Drs Ala-Laurila, Heikkinen, and Terho), Tampere, Finland, and the Biological Division, Smith Kline RIT, Rixensart, Belgium (Mr D'Hondt and Dr André).
Footnotes
Reprint requests to Department of Clinical Sciences, University of Tampere, 33520 Tampere 52, Finland (Dr Vesikari).
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