Staphylococcus epidermidis septicemia in children with leukemia and lymphoma
L. E. Friedman, A. E. Brown, D. R. Miller and D. Armstrong
Staphylococcus epidermidis is emerging as a cause of morbidity and
mortality in immunocompromised patients. From January 1980 through June
1982, there were 150 episodes of septicemia in 92 children with leukemia
and lymphoma at Memorial Sloan-Kettering Cancer Center, New York.
Staphylococcus epidermidis was the fourth most common organism isolated,
responsible for 12.7% of all septicemic episodes. Only nine of 53 isolates
were sensitive to methicillin; all were sensitive to vancomycin.
Staphylococcus epidermidis septicemia was associated with immunosuppressive
chemotherapy (94.7%); broad-spectrum antibiotics (79.0%); catheters and
drains (73.7%); neutropenia (63.2%); skin or soft-tissue infections
(42.1%); prior septicemia (42.1%); concurrent polymicrobial septicemia
(21.1%); and prolonged hospitalization (mean, 39 days). Of 19 patients, two
died. Increased awareness of the pathogenic potential of S epidermidis in
children with hematologic malignancies and prompt alteration of therapy to
an effective antimicrobial agent, in most cases vancomycin hydrochloride,
is required when the organism is isolated in patients known to be at risk
with clinical evidence of septicemia.
