Aminophylline reduces cerebral blood flow velocity in low-birth-weight infants
T. S. Rosenkrantz and W. Oh
Cerebral blood flow decreases substantially in the adult after a single
bolus injection of aminophylline. To determine if the cerebral circulation
of the low-birth-weight infant behaves in a similar manner, we measured
cerebral blood flow velocity (CBFV) in the anterior cerebral arteries of
nine infants treated with an intravenous bolus dose of 5 mg/kg of body
weight of aminophylline. A reduction in CBFV of 21% and 17% was observed at
60 and 120 minutes following the aminophylline administration. There was a
concurrent substantial reduction in PCO2 from 45 +/- 7 to 39 +/- 7 mm Hg
before and 120 minutes after the aminophylline administration,
respectively. The reduction in CBFV may be the result of a reduction in
PCO2 resulting from aminophylline treatment.
