This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Ted S. Rosenkrantz, MD; William Oh, MD

Am J Dis Child. 1984;138(5):489-491.

Abstract
• Cerebral blood flow decreases substantially in the adult after a single bolus injection of aminophylline. To determine if the cerebral circulation of the low-birth-weight infant behaves in a similar manner, we measured cerebral blood flow velocity (CBFV) in the anterior cerebral arteries of nine infants treated with an intravenous bolus dose of 5 mg/kg of body weight of aminophylline. A reduction in CBFV of 21% and 17% was observed at 60 and 120 minutes following the aminophylline administration. There was a concurrent substantial reduction in Pco₂ from 45±7 to 39±7 mm Hg before and 120 minutes after the aminophylline administration, respectively. The reduction in CBFV may be the result of a reduction in Pco₂ resulting from aminophylline treatment.

(AJDC 1984;138:489-491)

Author Affiliations
From the Department of Pediatrics, Women and Infants Hospital of Rhode Island, and the Section of Pediatrics, Brown University Program in Medicine, Providence. Dr Rosenkrantz is now with the University of Connecticut Health Center, Farmington.

Footnotes
Reprint requests to 50 Maude St, Providence, RI 02908 (Dr Oh).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Effects of a divided high loading dose of caffeine on circulatory variables in preterm infants
Hoecker et al.
Arch. Dis. Child. Fetal Neonatal Ed. 2006;91:F61-F64.
ABSTRACT | FULL TEXT  

Caffeine Impairs Cerebral and Intestinal Blood Flow Velocity in Preterm Infants
Hoecker et al.
Pediatrics 2002;109:784-787.
ABSTRACT | FULL TEXT