Acetaminophen overdose in young children. Treatment and effects of alcohol and other additional ingestants in 417 cases
B. H. Rumack
Four hundred seventeen young children who had ingested a potentially
serious amount of acetaminophen were examined and treated in a national
multicenter open study. Fifty-five had plasma levels in the potentially
toxic range, and 43 had a full course of acetylcysteine treatment. Three of
417 patients had SGOT values consistent with a hepatotoxic reaction. In the
children with toxic levels of acetaminophen those who had also ingested
alcohol had significantly lower SGOT levels than those who had not ingested
alcohol. Patients consuming acetaminophen who had also consumed
miscellaneous other ingestants were significantly more likely to be
lethargic than those who had not consumed other ingestants. The incidence
of transient hepatotoxic effects is significantly lower in children with
potentially toxic plasma levels than in adults with similar toxic plasma
levels. There were no deaths in this series of children.
Acetylcysteine for Acetaminophen Poisoning
Heard
NEJM 2008;359:285-292.
FULL TEXT
Age-specific pulmonary cytochrome P-450 3A1 expression in postnatal and adult rats
Day et al.
Am. J. Physiol. Lung Cell. Mol. Physiol. 2006;291:L75-L83.
ABSTRACT
| FULL TEXT
Paracetamol induced hepatotoxicity
Mahadevan et al.
Arch. Dis. Child. 2006;91:598-603.
ABSTRACT
| FULL TEXT
Liver
Pineiro-Carrero and Pineiro
Pediatrics 2004;113:1097-1106.
ABSTRACT
| FULL TEXT
Adult Toxicology in Critical Care: Part II: Specific Poisonings
Mokhlesi et al.
Chest 2003;123:897-922.
FULL TEXT
Acetaminophen Toxicity in Children
Committee on Drugs
Pediatrics 2001;108:1020-1024.
ABSTRACT
| FULL TEXT
Baseline Liver Function Tests Following Acetaminophen Ingestion: What is the Utility?
Ros and Conrad
CLIN PEDIATR 1994;33:569-570.
Repeated Acetaminophen Overdosing: Causing Hepatotoxicity in Children Clinical Reports and Literature Review
Henretig et al.
CLIN PEDIATR 1989;28:525-528.
