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Robert H. Slover, MD; Georgeanna J. Klingensmith, MD; Ronald W. Gotlin, MD; Jessica Radcliffe, MD

Am J Dis Child. 1984;138(3):314-317.

Abstract
• To evaluate the effectiveness of clonidine on growth-hormone (GH) release in prepubertal children, and to distinguish between a central -adrenergic effect and a corticotropin-cortisol—mediated response, we measured serum glucose, corticotropin, cortisol, and GH concentrations following levodopa, arginine hydrochloride, and clonidine hydrochloride stimulation in 15 euthyroid children who had short stature. We found that clonidine is an effective and safe stimulator of GH release and provided a clearer distinction between GH-deficient and non—GH-deficient young persons than levodopa or arginine. The action of clonidine is not corticotropin-cortisol mediated.

(AJDC 1984;138:314-317)

Author Affiliations
From the Department of Pediatrics, University of Colorado School of Medicine, Denver (Drs Klingensmith, Gotlin, and Radcliffe) and Fitzsimons Army Medical, Aurora, Colo.

Footnotes
The views of the authors do not purport to reflect the positions of the Department of the Army or the Department of Defense.

Reprint requests to University of Colorado School of Medicine, 4200 E Ninth Ave, Denver, CO 80262 (Dr Gotlin).

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